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Challenging Cases in Allergic and Immunologic Diseases of the Skin offers clinicians a wide range of challenging cases that are certain to provide hours of thoughtful and instructive review. Using a case study format and including excellent quality color images, Challenging Cases in Allergic and Immunologic Diseases of the Skin consists of five parts and 20 chapters. The chapters cover such areas as allergic rhinitis, allergic diseases of the eye, drug-induced urticaria, cosmetic allergy, drug allergy, latex allergy, atopic dermatitis, vasculitis, and a range of other commonly seen disorders of the skin. Each chapter comprises at least two cases that are followed by a differential diagnosis, discussion, and five multiple choice questions for thoughtful stimulation and excellent value as a teaching tool. Comprehensive, concise, and well-designed in presentation, Challenging Cases in Allergic and Immunologic Diseases of the Skin is a one-of-a-kind resource that will become a standard resource for all clinicians who care for patients with allergic and immunologic diseases of the skin.

Medicine & Public Health. --- Allergology. --- Dermatology. --- Primary Care Medicine. --- General Practice / Family Medicine. --- Medicine. --- Allergy. --- Family medicine. --- Emergency medicine. --- Médecine --- Allergie --- Dermatologie --- Médecine familiale --- Médecine d'urgence --- Skin --- Skin Diseases --- Hypersensitivity --- Immune System Diseases --- Diseases --- Immunological aspects. --- Diseases. --- diagnosis --- therapy --- Diagnosis --- Therapy

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The recent explosion of new information about the pathology, pathophysiology, clinical classification, imaging, and treatment of multiple sclerosis (MS) has dramatically opened the way to a deeper understanding of the disease and a more effective therapeutic landscape for patients. In Multiple Sclerosis: Etiology, Diagnosis, and New Treatment Strategies, leading MS physicians synthesize current concepts about the evaluation, treatment, and future directions in MS. On the evaluation side, the authors review the use of magnetic resonance imaging (MRI), magnetic resonance spectroscopy, functional MRI, and three-dimensional MRI, and consider the rapidly developing body of pathologic information they have yielded. On the treatment side, the focus is on recently approved medications (Novantrone), new indications for medications (CHAMPS Trial), medications in development (Oral Interferon Tau, Oral Copaxone, and Oral Cellcept), immunosuppressive therapy for both progressive disease and symptomatic therapy; the current medications for treating relapsing-remitting MS (Avonex, Betaseron, and Copaxone) are also discussed. For future directions, the authors present the current best thinking, as well as the latest discoveries in immunology relating to MS, including groundbreaking B-cell research, its applications to specific immunotherapies, and the use of immune markers for tracking the disease. Additional chapters cover the mechanism and application of myelin repair, bone marrow transplantation, combination therapy, and specific immunomodulatory treatments. Comprehensive and up-to-date, Multiple Sclerosis: Etiology, Diagnosis, and New Treatment Strategies reviews all the current immunological, neuropsychological, imaging, and pregnancy issues associated with MS and shows how each is contributing to the still ongoing development of more efficacious therapies.

Multiple Sclerosis --- Multiple sclerosis. --- Sclérose en plaques --- therapy. --- diagnosis. --- etiology. --- Multiple sclerosis --- Diagnosis --- Demyelinating Autoimmune Diseases, CNS --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Autoimmune Diseases of the Nervous System --- Demyelinating Diseases --- Autoimmune Diseases --- Nervous System Diseases --- Immune System Diseases --- Diseases --- Neurology --- Medicine --- Health & Biological Sciences --- Treatment. --- Diagnosis. --- MS (Disease) --- Sclerosis, Multiple --- Medicine. --- Neurology. --- Medicine & Public Health. --- Demyelination --- Myelin sheath --- Virus diseases --- Nervous system --- Neuropsychiatry --- Neurology .

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Our goal for this book is to examine the contemporary therapy of rheumatoid arthritis (RA) from the increasingly important perspective of impact upon quality of life, costs and long-term health outcomes. For too long the focus has been on short­ term, symptomatic, and surrogate indicator outcomes. Yet RA is a life-long disor­der with the majority of impact on an individual patient many years following onset. Further, even in the short-term, researchers and rheumatologists have tended to emphasize measurements of disease activity such as joint counts, ESR and physi­cian's opinion as to the amount of disease activity present. It is only relatively recently that measures of structural damage, quality of life and impact on broad domains of health have been given increasing emphasis. Also, the significance of early treatment of RA in order to optimise long-term outcomes has a relatively short history [1]. We have been focussed on the disease processes as surrogates for long­ term outcomes. Until the short-term process measures are validated as surrogates of long-term effects we should also turn our attention to outcomes of disease and the impact of our management on those outcomes [2). In our view, this book is especially timely. We are at the dawn of a revolution in the management of RA and other complex immunological inflammatory disorders because their molecular, genetic and environmental mechanisms are being unrav­elled. In the process, we are revealing a substantial number of novel and significant targets for pharmacotherapy.

Medicine & Public Health. --- Medicine/Public Health, general. --- Medicine. --- Médecine --- Antirheumatic agents. --- Rheumatoid arthritis -- Chemotherapy. --- Rheumatoid arthritis. --- Antirheumatic agents --- Rheumatoid arthritis --- Rheumatic Diseases --- Autoimmune Diseases --- Therapeutic Uses --- Arthritis --- Pharmacologic Actions --- Musculoskeletal Diseases --- Connective Tissue Diseases --- Joint Diseases --- Immune System Diseases --- Arthritis, Rheumatoid --- Antirheumatic Agents --- Skin and Connective Tissue Diseases --- Diseases --- Chemical Actions and Uses --- Chemicals and Drugs --- Health & Biological Sciences --- Pharmacy, Therapeutics, & Pharmacology --- Chemotherapy --- Chemotherapy. --- Adjuvant arthritis --- Arthritis deformans --- Arthrosis deformans --- Rheumatic gout --- Anti-rheumatic agents --- Autoimmune diseases --- Blood hyperviscosity syndrome --- Rheumatism --- Analgesics --- Anti-inflammatory agents --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce